PREDICT™ Comprehensive Hereditary Cancer Risk Assessment

Comprehensive Suite of Genetic Tests

LabSolutions is pleased to offer its clients a comprehensive suite of genetic tests, allowing the physicians we serve to provide truly personalized healthcare. Coupling the latest in laboratory technologies with highly trained genomic scientists and counselors keeps our clients on the cutting edge of molecular science. Next Generation Sequencing (NGS) based screening for mutations known to affect an individual’s risk of developing hereditary cancer is performed at our state-of-the-art, CLIA certified and COLA accredited facility. PREDICT™ test results, along with an ordering and treating provider’s expertise, are used to make better informed clinical decisions.

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Cancer is a disorder in which the normal control of cell growth is lost, causing abnormal proliferation of the affected cells. Inherited genetic mutations may increase a patient’s risk of developing cancer through numerous mechanisms, depending on the aberrant functions of the mutated parent gene. Mutations in genes involved in mismatched repair of damaged DNA are particularly likely to lead to a higher cancer risk.

Hereditary or Predisposition Cancer Genomics

Molecular testing looks for specific inherited changes (mutations) in a person’s genetic make-up. Genetic mutations may have multiple different effects on a patient’s health. Mutations that are harmful may increase a person’s chance, or risk, of developing a disease such as cancer. Inherited mutations are thought to play a role in 5-10% of all cancers. These particular conditions are considered hereditary and appropriate genetic testing may be used to determine an individual’s risk.

Some people inherit mutation(s) in the germline, allowing for the mutations to be passed on from their parents and to their children. There are two classes of cellular genes: oncogenes and tumor suppressor genes. Often, multiple genetic mutations in a single individual are responsible for the development of hereditary cancers.

Common Hereditary Cancers and Cancer Syndromes:

  • Lynch Syndrome (MLH1, MSH2, MSH6, PMS2, EPCAM)
  • Uterine Cancer (MLH1, MSH2, EPCAM, MSH6, PMS2)
  • Li-Fraumeni Syndrome (TP53)
  • Colon Cancer (APC, BMPR1A, EPCAM)
  • Endometrial Cancer (EPCAM, MLH1, MSH2, MSH6)
  • Breast and Ovarian Cancer (BRCA1, BRCA2)

Family Risk Insight:

  • Cancer that occurs in unusually young ages
  • Multiple childhood cancers in siblings
  • Cancer occurring in an unusual gender (e.g., breast cancer in male family members)
  • Multiple cancers in a single person
  • Cancer in organ pairs (e.g., cancers in both kidneys)
  • Rare cancers occurring in multiple members of the family

Why Should Patients Get Tested?

They may begin to get cancer screens earlier and more often

They may begin to monitor themselves closely for signs or symptoms of a particular type of cancer

They may initiate healthy lifestyle changes

They may look in to preventive medications or surgery if recommended by a healthcare provider

Get more details about the PREDICT™ test here: