PHARMACOGENOMICS

LABSOLUTIONS offers a comprehensive suite of genetic tests, allowing providers to personalize treatment plans. Coupling the latest laboratory technologies with highly trained scientists and counselors keeps our clients cutting-edge.

Pharmacogenomics is the study of how human genetic variation affects an individual’s response to drug therapies. Understanding the genetic makeup of a patient allows a physician to predict how a prescribed drug will interact with that patient, giving the clinician insight into efficacy and potential undesired drug effects and interactions.

Large families of enzymes (and transporters) involved in first-pass metabolism reside in our liver and wait for their target substrates to present themselves, setting off a chain reaction of metabolic events.  In order to predict how efficiently an enzyme or transporter will perform its duties, we look to an individual’s DNA.  By isolating and examining the regions of a patient’s DNA that code for the enzymes of interest, we can better predict how the enzymes will interact with their targets, giving us a peek into the overall metabolic efficiency of a given enzymatic pathway.  This data can then be used to help physicians stay clear of drugs that would be metabolized by inefficient pathways and guide them towards drugs that use stronger metabolic pathways.  Greater understanding of how a patient processes medication also allows us to predict the buildup of often toxic drug products as well as better predict dangerous interactions between drugs and/or their metabolites.

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FDA studies estimate that 7% of hospitalized patients have a serious adverse drug reaction with a fatality rate of 0.32%.

By isolating and examining the regions of a patient’s DNA that code for the enzymes of interest, we can provide the following answers:

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How well does the patient metabolize drugs and what personal factors are being used to aid in drug selection?

RESPONSE™ acts as a lifelong prescribing roadmap, steering the provider towards drugs that are metabolized efficiently and away from those that are not. 

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Is there a system to identify when a patient is taking a medication that is poorly suited for them?

RESPONSE™ acts as a safeguard, protecting both physician and patient from undesirable Adverse Drug Reactions.

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How do enzymes interact with their targets and how does the patient's genetic makeup affect these interactions?

Enzymes modify drugs into their active and inactive metabolites. A person’s genetic makeup may seriously affect how well certain enzymes perform.

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How can a physician mitigate drug-drug interactions when a patient is prescribed multiple medications?

RESPONSE™ flags potentially dangerous interactions between drugs and often suggests suitable alternatives.

There are more than 2,216,000 serious ADRs in hospitalized patients, causing over 106,000 deaths annually.

Annual ADR Deaths

Why Test?

Patients have differences in DNA that impact drug metabolism which may increase their likelihood of an adverse drug reaction:

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More than 85% of the population have detectable variations in their DNA that increase their risk for adverse drug reactions.

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Adverse Drug Reactions are the 4th leading cause of death nationwide with more than 8.6 million cases reported annually.

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The FDA highlights pharmacogenomics data for more than 130 prescription medications, indicating their strong support for testing.

Who To Test?

LabSolutions advises pharmacogenomics testing for patients that meet one or more of the following conditions:

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Patients that experience less than optimal results from prescribed medications.

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Patients with a personal or family history of adverse drug reactions in response to certain medications.

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Polypharmacy patients; those taking multiple prescription medications for multiple chronic conditions.

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RESPONSE™

Comprehensive Pharmacogenomic Analysis

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RESPONSEpain™

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RESPONSEcardio™

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RESPONSEcancer™

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RESPONSEpsych™