Comprehensive Hereditary Cancer Risk Asessment
Next Generation Sequencing (NGS) based screening for mutations known to effect an individuals risk of developing hereditary cancer is performed at our state-of-the-art, CLIA certified facility. PREDICT test results, along with a treating provider’s expertise, are used to make better informed treatment and/or monitoring decisions.
Hereditary or Predisposition Cancer Genomics
Genetic Testing looks for specific inherited changes (mutations) in a person’s genetic make-up. Genetic mutations can have harmful, beneficial, neutral, or uncertain effects on health. Mutations that are harmful may increase a person’s chance, or risk, of developing a disease such as cancer. Inherited mutations mutations are thought to play a role in 5-10% of all cancers. These particular disease states are known as hereditary cancers and proper genetic testing can be used to determine an individuals risk.
Some people inherit mutation(s) in the germline, potentially allowing for the cancers associated with the same to be passed on. There are two classes of cellular genes: oncogenes and tumor suppressor genes. Often, multiple genetic mutations in a single individual are responsible for the development of hereditary cancers.
Cancer is a disorder in which normal control of cell growth is lost—causing abnormal proliferation of the effected cells. Inherited genetic mutations can increase a person’s risk of developing cancer through a variety of contrivances, depending on the functions of the mutated gene. Mutations in genes that control the repair of damaged DNA and cell growth are particularly likely to be associated with an increased risk of cancer.
COMMON HEREDITARY CANCERS AND CANCER SYNDROMES
Lynch Syndrome (MLH1, MSH2, MSH6, PMS2, EPCAM)
Colon Cancer (APC, BMPR1A, EPCAM)
Uterine Cancer (MLH1, MSH2, EPCAM, MSH6, PMS2)
Endometrial Cancer (EPCAM, MLH1, MSH2, MSH6)
Li-Fraumeni Syndrome (TP53)
Breast and Ovarian Cancer (BRCA1, BRCA2)
WHO SHOULD GET TESTED
If one of your family members, however distant, has been diagnosed with cancer, there is a chance that you inherited a gene mutation that not only increases your personal risk of developing cancer, but may also be passed on to your offspring—potentially increasing their risk of developing cancer.
If you suspect that you or someone you know may have an increased risk for cancer–-based on factors like abnormal familial cancer history or identify with an at-risk ethnic population (such as Ashkenazi Jewish ancestry)—you may want to discuss advanced genomic testing options like PREDICT™ with your healthcare provider.
BENEFITS OF TESTING
Those who are carriers of hereditary cancer gene mutations, may be at risk of developing cancer earlier in life, as compared to members of the general population. The sooner genetic testing is performed, the more likely it is that this increased risk can be managed appropriately.
“The sooner genetic testing is performed, the more likely it is that this increased risk can be managed appropriately.”
Who identify with an at-risk ethnic population
With abnormal familiar cancer history
Genomic DNA from the submitted specimen is enriched for the complete coding regions and splice site junctions of genes assessed by PREDICT ™ using a proprietary targeted capture system developed by LabSolutions. All sequence alterations are described according to nomenclature guidelines set forth by the Human Genome Variation Society (HGVS). Benign and likely benign variants, if present, are not reported but are available upon request.